Genital Chlamydia prevalence in Europe and non-European high income countries: systematic review and meta-analysis

Autorid: Redmond S, Alexander-Kisslig K, Uusküla A
Väljaandja/tellija: PLOS Medicine
Märksõnad: klamüdioos, sugulisel teel nakkavad haigused, levimus, Euroopa
Välja antud: 2015
Tüüp: Teaduslik artikkel/kogumik
Viide: Redmond SM, Alexander-Kisslig K, Uusküla A. Genital Chlamydia prevalence in Europe and non-European high income countries: systematic review and meta-analysis. PLOS Medicine 2015;10(1):e0115753.
Alamvaldkonnad:Tervisenäitajate siseriiklik ja rahvusvaheline võrdlus
Kirjeldus: Accurate information about the prevalence of Chlamydia trachomatis is needed to assess national prevention and control measures.
We systematically reviewed population-based cross-sectional studies that estimated chlamydia prevalence in European Union/European Economic Area (EU/EEA) Member States and non-European high income countries from January 1990 to August 2012. We examined results in forest plots, explored heterogeneity using the I2 statistic, and conducted random effects meta-analysis if appropriate. Meta-regression was used to examine the relationship between study characteristics and chlamydia prevalence estimates.
We included 25 population-based studies from 11 EU/EEA countries and 14 studies from five other high income countries. Four EU/EEA Member States reported on nationally representative surveys of sexually experienced adults aged 18-26 years (response rates 52-71%). In women, chlamydia point prevalence estimates ranged from 3.0-5.3%; the pooled average of these estimates was 3.6% (95% CI 2.4, 4.8, I2 0%). In men, estimates ranged from 2.4-7.3% (pooled average 3.5%; 95% CI 1.9, 5.2, I2 27%). Estimates in EU/EEA Member States were statistically consistent with those in other high income countries (I2 0% for women, 6% for men). There was statistical evidence of an association between survey response rate and estimated chlamydia prevalence; estimates were higher in surveys with lower response rates, (p = 0.003 in women, 0.018 in men).
Population-based surveys that estimate chlamydia prevalence are at risk of participation bias owing to low response rates. Estimates obtained in nationally representative samples of the general population of EU/EEA Member States are similar to estimates from other high income countries.