Effects of serotonin transporter promoter polymorphism (5-httlpr) and neuropeptide y gene variants on alcohol use in young adults

Autorid: Vaht M
Väljaandja/tellija: Tartu Ülikool: Psühholoogia osakond
Märksõnad: noored, alkohol, geenid
Välja antud: 2012
Tüüp: Magistritöö
Nimi SuurusFormaat
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Alamvaldkonnad:Sõltuvusainete tarvitamine
Kirjeldus: Objective: To elucidate the possible main effects and interactions of 5-HT transporter gene-linked polymorphic region (5-HTTLPR) and two functional polymorphisms in the neuropeptide Y (NPY) gene - rs16139, rs16147 - on alcohol use in young adults.

Methods: The sample of the longitudinal Estonian Children Personality Behaviour and Health Study (initially cohorts of 9 and 15 year old children) was initially examined in 1998. In the given study, data collected at the time when the younger cohort (n=580) was 18 and the older (n=654) 25 years old was used. Subjects filled self-report questionnaires about their alcohol consumption; in addition, subjects from the older cohort were interviewed by a psychologist in order to determine the occurrence of alcohol use disorder.

Results: In the given sample, the subjects from the younger cohort started consuming alcohol at an earlier age than the subjects from the older cohort. Alcohol consumption was more problematic among male subjects, both in the older and younger cohort. In interaction with subjects¿ gender and cohort, 5-HTTLPR had significant effects on the age when subjects first consumed alcohol. Subjects who were NPY rs16139 C allele carriers and also had NPY rs16147 T/T genotype were found to have more problematic alcohol use. Some interactive effects on alcohol use between 5-HTTLPR and NPY polymorphisms were also identified in the course of exploratory data analysis.

Conclusions: Serotonergic and NPY-ergic systems have a role in youth¿s alcohol consumption, but the effects are dependent on gender and cohort.