Pealkiri: 

Immunoglobulin G Glycosylation Profiling in Patients with Gastric Cancer

Autorid: Kodar K
Väljaandja/tellija: Tallinna Tehnikaülikool: Geenitehnoloogia osakond
Märksõnad: kasvajad, mittenakkushaigused, geenid, diagnostika
Välja antud: 2012
Tüüp: Doktoritöö
Failid:
Nimi SuurusFormaat
Kodar2012.pdf7.49 MBAdobe PDF
Alamvaldkonnad:Mittenakkushaigused
Kirjeldus: A general objective of this study was to gain further knowledge about the
glycosylation of human IgG in gastric cancer.

This was approached through the specific aims:
(i) to investigate the glycosylation profile of the total and antigen specific IgG in patients with gastric cancer and controls (healthy blood donors and patients with benign gastric disorders) using lectins of various sugar specificities;
(ii) to profile the Fc N glycans of IgG by the liquid chromatography electospray ionization mass spectrometry (LC-ESI-MS) method;
(iii) to evaluate whether the putative changes in the IgG glycosylation profile could be used to diagnose and prognosticate of stomach cancer.