Pealkiri: 

The relationship between serotonin transporter gene promoter polymorphism and serum lipid levels at young age in a longitudinal population-representative study

Autorid: Tomson K , Merenäkk L , Loit H-M , Mäestu J , Harro J
Väljaandja/tellija: Prog Neuropsychopharmacol Biol Psychiatry
Märksõnad: geenid, psühhiaatria, vaimne tervis, lapsed
Välja antud: 2011
Tüüp: Teaduslik artikkel/kogumik
Viide: Tomson K, Merenäkk L, Loit HM, et al. The relationship between serotonin transporter gene promoter polymorphism and serum lipid levels at young age in a longitudinal population-representative study. Prog Neuropsychopharmacol Biol Psychiatry 2011;35(8):1857-62.
Link: http://www.sciencedirect.com/science/article/pii/S027858461100251X
Alamvaldkonnad:Vaimne tervis
Kirjeldus: The serotonin transporter gene promoter region polymorphism (5-HTTLPR) has been linked to psychiatric disorders, mostly anxiety and affective disorders. In elderly populations 5-HTTLPR polymorphism has also been reported to be associated with serum lipid levels. We have examined the interaction of the 5-HTTLPR polymorphism and the markers of lipid metabolism at young age in a longitudinal, population-representative cohort study. The sample of the Estonian Children Personality Behaviour and Health Study (initially cohorts of 9 and 15 year old children, complete lipid and genotype data for n=1176) was examined throughout 10 years. Subjects were genotyped and the levels of low-density lipoproteins, high-density lipoproteins, triglycerides, and total cholesterol were measured. Children and adolescents carrying the s allele of the 5-HTTLPR polymorphism had lower levels of low-density lipoprotein and total cholesterol. At the age of 25, the s allele carriers had higher levels of high-density lipoproteins. These associations were independent of gender. Thus the 5-HTTLPR can be associated with the serum lipid levels and in particular low-density lipoproteins already in a young age.