Pealkiri: 

Effects of the serotonin transporter (5-HTTLPR) and alfa2A-adrenoceptor (C-1291G) genotypes on substance use in children and adolescents: a longitudinal study

Autorid: Merenäkk L , Mäestu J , Nordquist N , Parik J , Oreland L , Loit H-M , Harro J
Väljaandja/tellija: Psychopharmacology
Märksõnad: geenid, lapsed, noored, alkohol, suitsetamine, demograafilised näitajad, sõltuvushäired
Välja antud: 2011
Tüüp: Teaduslik artikkel/kogumik
Viide: Merenäkk L, Mäestu J, Nordquist N,et al. Effects of the serotonin transporter (5-HTTLPR) and alfa2A-adrenoceptor (C-1291G) genotypes on substance use in children and adolescents: a longitudinal study. Psychopharmacology 2011;215(1):13-22.
Link: http://www.springerlink.com/content/d8p874u0v0r62807/
Alamvaldkonnad:Demograafilised näitajad
Sõltuvusainete tarvitamine
Kirjeldus: Rationale and objective
Twin studies suggest that substance use initiation in children and adolescents is determined primarily by environmental influences, whereas the establishment of use patterns is strongly controlled by genetic factors. The present study analysed the effects of the serotonin transporter promoter polymorphism [5-HT transporter gene-linked polymorphic region (5-HTTLPR)] and the ¿2A-adrenoceptor C-1291G genotype (ADRA2A C-1291G) as well as their interaction effects on alcohol, tobacco and drug use from preadolescence to the late adolescence.

Methods
Initial sample of 9-year-old children of Estonian Children Personality Behaviour and Health Study (n=583) was recalled at ages 15 and 18. Participants reported in all
waves how frequently they smoked and used alcohol and illicit drugs.

Results
5-HTTLPR had age-dependent effects on alcohol, tobacco and drug use: substance use did not differ by genotype at age 9, but at age 15, the participants with the short (s)/s genotype had higher tobacco use, and at age 18, they were more active alcohol, drug and tobacco users. Effects of ADRA2A C-1291G on drug use were dependent on gender, age and 5-HTTLPR. Males (age 18) with
ADRA2A CG genotype, when compared to other participants, tended to have higher drug use especially when they had s/s genotype of 5-HTTLPR.

Conclusions
Our results reveal that expression of genetic vulnerability for substance use in children and adolescents may depend on age, gender, interaction of genes, and type of substance.